Track Record:

Article

2026

• "NVL2-interacting protein CWF19L2 is required for debranching of intron-derived lariat RNAs"
  Oshima R, Izumikawa K, Yamazaki R, Iwakawa Y, Tamura M, Shida T, Miyao S, Nagahama M
  Biochemical and Biophysical Research Communications Volume 796, 153160 (2026).

  • DOI: 10.1016/j.bbrc.2025.153160

2025

• "Molecular basis of the autoregulatory mechanism of motor neuron-related splicing factor 30"
  Izumikawa K*, Shida T*, Onodera Y, Tashima, Miyao S, Suda T, Suda Y, Kamimura R, Nagai M, Sugihara M, Noguchi T, Nagahama M. (*Equal contribution)
  Journal of Biological Chemistry 301:110522. (2025).

  • DOI: 10.1016/j.jbc.2025.110522
• "Data for proteomic analysis of the chaperone-like nuclear VCP-like 2 (NVL2)-associated proteins."
  Izumikawa K, Nobe Y, Taoka M, Nagahama M.
  Journal of Proteome Data and Methods Volume 7, 1- (2025).

  • DOI: 10.14889/jpdm.2025.0001
• "Dual synthesis pathways of scaRNA28 via intronic processing of transformation/transcription domain-associated protein transcripts and a novel independent transcription unit"
  Izumikawa K, Shida T, Ishikawa H, Miyao S, Ohga T, Taoka M, Nobe Y, Nakayama H, Nagahama M.
  RNA biology 22(1):1-12. (2025).

  • DOI: 10.1080/15476286.2025.2513133
• "Molecular basis of the autoregulatory mechanism of motor neuron-related splicing factor 30"
  Izumikawa K, Shida T, Onodera Y, Tashima, Miyao S, Suda T, Suda Y, Sugihara M, Noguchi T, Nagahama M.
  bioRxiv (Preprint) (2025).

  • DOI: 10.1101/2025.03.04.641417
• "SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis."
  Ogawa A*, Izumikawa K*, Tate S*, Isoyama S, Mori M, Fujiwara K, Watanabe S, Ohga T, Jo U, Taniyama D, Kitajima S, Tanaka S, Onji H, Kageyama S, Yamamoto G, Saito H, Morita YT, Okada M, Natsumeda M, Nagahama M, Murai J. (*Equal contribution)
  Molecular Cell 85, 5 (2025).

  • URL
  • DOI: 10.1016/j.molcel.2025.01.008

2024

• "Pre-ribosomal WDR74 module coordinates the early and late pre-rRNA processing stages for the NVL2-mediated regulation of 60S ribosome biogenesis"
  Hirooka Y, Izumikawa K, Miyao S, Ohga T, Nobe Y, Taoka M, Nagahama M.
  Biochemical and Biophysical Research Communications 744:151175 (2024).

  • DOI: 10.1016/j.bbrc.2024.151175
• "Mitoribosome structure with cofactors and modifications reveals mechanism of ligand binding and interactions with L1 stalk"
  Singh V, Itoh Y, Del'Olio S, Hassan A, Naschberger A, Flygaard RK, Nobe Y, Izumikawa K, Aibara S, Andréll J, Whitford PC, Barrientos A, Taoka M, Amunts A.
  Nature Communications 15(1):4272. (2024).

  • DOI: 10.1038/s41467-024-48163-x.

2023

• "Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins"
  Komuro R, Honda Y, Yanaizu M, Nagahama M, Kino Y.
  Cells 12(4):602 (2023).

  • DOI: 10.3390/cells12040602
• "Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications."
  Singh V, Itoh Y, Del'Olio S, Hassan A, Naschberger A, Flygaard RK, Nobe Y, Izumikawa K, Aibara S, Andréll J, Whitford PC, Barrientos A, Taoka M, Amunts A.
  bioRxiv (Preprint) (2023).

  • DOI: 10.1101/2023.05.24.542018
• "Brucella effectors NyxA and NyxB target SENP3 to modulate the subcellular localisation of nucleolar proteins."
  Louche A, Blanco A, Lacerda TLS, Cancade-Veyre L, Lionnet C, Bergé C, Rolando M, Lembo F, Borg JP, Buchrieser C, Nagahama M, Gérard FCA, Gorvel JP, Gueguen-Chaignon V, Terradot L, Salcedo SP.
  Nature Communications 14(1):102. (2023).

  • DOI: 10.1038/s41467-022-35763-8

2022

• "MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA processing"
  Miyao S, Saito K, Oshima R, Kawahara K, Nagahama M.
  Biochemical and Biophysical Research Communications (2022).

  • DOI: 10.1016/j.bbrc.2022.11.018
• "MPP6 stimulates both RRP6 and DIS3 to degrade a specified subset of MTR4-sensitive substrates in the human nucleus."
  Fujiwara N, Shigemoto M, Hirayama M, Fujita KI, Seno S, Matsuda H, Nagahama M, Masuda S.
  Nucleic Acids Research 50(15):8779-8806 (2022).

  • DOI: 10.1093/nar/gkac559
• "TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2."
  Egawa N, Izumi Y, Suzuki H, Tsuge I, Fujita K, Shimano H, Izumikawa K, Takahashi N, Tsukita K, Enami T, Nakamura M, Watanabe A, Naitoh M, Suzuki S, Seki T, Kobayashi K, Toda T, Kaji R, Takahashi R, Inoue H.
  Scientific Reports 12:7988. (2022).

  • DOI: 10.1038/s41598-022-12133-4

2021

• "Interactome analysis of the Tudor domain-containing protein SPF30 which associates with the MTR4-exosome RNA-decay machinery under the regulation of AAA-ATPase NVL2."
  Ishida YI, Miyao S, Saito M, Hiraishi N, Nagahama M.
  The International Journal of Biochemistry & Cell Biology 132:105919. (2021).

  • DOI: 10.1016/j.biocel.2021.105919

2020

• "Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation."
  Sun X, Kawata K, Miki A, Wada Y, Nagahama M, Takaya A, Akimitsu N.
  BioScience Trends 14:255-262. (2020).

  • DOI: 10.5582/bst.2020.03085
• "A cellular model of albumin endocytosis uncovers a link between membrane and nuclear proteins. "
  Urae S, Harita Y, Udagawa T, Ode KL, Nagahama M, Kajiho Y, Kanda S, Saito A, Ueda HR, Nangaku M, Oka A.
  Journal of Cell Science 133:jcs242859. (2020).

  • DOI: 10.1242/jcs.242859
• "Systematic Analysis of Targets of Pumilio-Mediated mRNA Decay Reveals that PUM1 Repression by DNA Damage Activates Translesion Synthesis."
  Yamada T, Imamachi N, Imamura K, Taniue K, Kawamura T, Suzuki Y, Nagahama M, Akimitsu N.
  Cell Reports 31:107542 (2020).

  • DOI: 10.1016/j.celrep.2020.107542